RNA‐protein interactions play essential roles in regulating gene expression. While some
RNA‐protein interactions are “specific”, that is, the RNA‐binding proteins preferentially bind …

摘要蛋白质-DNA 识别在生物过程中起着重要作用, 其结合是由序列特异性识别和结构特征共同
影响的. 为了研究残基类型和蛋白质二级结构对结合的贡献, 本文构建了一个新的非冗余蛋白质 …

The repair of DNA double-strand breaks by homologous recombination is of crucial
importance for maintaining genomic stability. Two major players during this repair pathway …

Rationale SARS-CoV-2 infection of the respiratory system can progress to a life threatening
multi-systemic disease, mediated via an excess of cytokines (“cytokine storm”), but the …

Abstract Background The RNA-Recognition motif (RRM) is a protein domain that binds
single-stranded RNA (ssRNA) and is present in as much as 2% of the human genome …

A significant part of biology involves the formation of RNA–protein complexes. X-ray
crystallography has added a few solved RNA–protein complexes to the repertoire; however …

Modulating protein interaction pathways may lead to the cure of many diseases. Known
protein–protein inhibitors bind to large pockets on the protein–protein interface. Such large …

RNA–RNA interactions play fundamental roles in gene and cell regulation. Therefore,
accurate prediction of RNA–RNA interactions is critical to determine their complex structures …

Covalent modifications of standard DNA/RNA nucleobases affect epigenetic regulation of
gene expression by modulating interactions between nucleic acids and protein readers. We …

Protein–nucleic acids interactions, which involve the binding of protein with RNA or/and
DNA molecules, play crucial roles in many biochemical pathways. Experimental studies of …