Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed
countries. It is characterized by progressive fibro-calcific remodelling and thickening of the …

Calcific aortic valve disease (CAVD), previously thought to represent a passive
degeneration of the valvular extracellular matrix (VECM), is now regarded as an intricate …

Aims Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of
an expanded somatic blood cell clone without other haematological abnormalities, was …

Background: Calcific aortic valve disease is characterized by an abnormal mineralization of
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …

Background Emerging evidences have indicated that long non-coding RNAs (lncRNAs) play
vital roles in cardiovascular physiology and pathology. The lncRNA MALAT1, a highly …

Objective The purpose of the present study was to comprehensively compare the phenotype
profile of infiltrated macrophages in human noncalcified and calcific aortic valves, and to …

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy
exists outside of prosthetic replacement. The increasing proportion of younger and more …

Calcified aortic valve disease (CAVD) is a common cardiovascular disease in elderly
individuals. Although it was previously considered a degenerative disease, it is, in fact, a …

Aims Oxidatively modified lipoproteins may promote the development/progression of calcific
aortic valve stenosis (CAVS). Oxidative transformation of low-density lipoprotein (OxLDL) …

Calcific aortic valve disease (CAVD) is highly prevalent and has no pharmaceutical
treatment. Surgical replacement of the aortic valve has proved effective in advanced disease …