Considering the methodological limitations in the evidence base of antidepressants for depression: a reanalysis of a network meta-analysis
K Munkholm, AS Paludan-Müller, K Boesen - BMJ open, 2019 - bmjopen.bmj.com
Objectives To investigate whether the conclusion of a recent systematic review and network
meta-analysis (Cipriani et al) that antidepressants are more efficacious than placebo for …
meta-analysis (Cipriani et al) that antidepressants are more efficacious than placebo for …
Depressive disorders: Treatment failures and poor prognosis over the last 50 years
TP Blackburn - Pharmacology research & perspectives, 2019 - Wiley Online Library
Depression like many diseases is pleiotropic but unlike cancer and Alzheimer's disease for
example, is still largely stigmatized and falls into the dark shadows of human illness. The …
example, is still largely stigmatized and falls into the dark shadows of human illness. The …
Integrating psychotherapy and psychopharmacology: psychedelic-assisted psychotherapy and other combined treatments
KT Greenway, N Garel, L Jerome… - Expert Review of …, 2020 - Taylor & Francis
Introduction Combinations of psychotherapy with antidepressants are gold-standard
psychiatric treatments. They operate through complex and interactional mechanisms, not …
psychiatric treatments. They operate through complex and interactional mechanisms, not …
Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety disorders in adults
E Van Leeuwen, ML van Driel… - Cochrane Database …, 2021 - cochranelibrary.com
Background Depression and anxiety are the most frequent indication for which
antidepressants are prescribed. Long‐term antidepressant use is driving much of the …
antidepressants are prescribed. Long‐term antidepressant use is driving much of the …
How effective are antidepressants for depression over the long term? A critical review of relapse prevention trials and the issue of withdrawal confounding
MP Hengartner - Therapeutic advances in …, 2020 - journals.sagepub.com
The aim of this article is to discuss the validity of relapse prevention trials and the issue of
withdrawal confounding in these trials. Recommendations for long-term antidepressant …
withdrawal confounding in these trials. Recommendations for long-term antidepressant …
[HTML][HTML] Statistically significant antidepressant-placebo differences on subjective symptom-rating scales do not prove that the drugs work: effect size and method bias …
MP Hengartner, M Plöderl - Frontiers in psychiatry, 2018 - frontiersin.org
Following the publication of a recent meta-analysis by Cipriani et al.(1), various opinion
leaders and news reports claimed that the effectiveness of antidepressants has been …
leaders and news reports claimed that the effectiveness of antidepressants has been …
The 'patient voice': patients who experience antidepressant withdrawal symptoms are often dismissed, or misdiagnosed with relapse, or a new medical condition
A Guy, M Brown, S Lewis… - Therapeutic Advances in …, 2020 - journals.sagepub.com
Background: Stopping antidepressants commonly causes withdrawal symptoms, which can
be severe and long-lasting. National Institute for Health and Care Excellence (NICE) …
be severe and long-lasting. National Institute for Health and Care Excellence (NICE) …
Protracted withdrawal syndrome after stopping antidepressants: a descriptive quantitative analysis of consumer narratives from a large internet forum
MP Hengartner, L Schulthess… - Therapeutic …, 2020 - journals.sagepub.com
Background: Protracted withdrawal syndrome (PWS) after stopping antidepressants
(frequently also referred to as post-acute withdrawal syndrome or PAWS) has been …
(frequently also referred to as post-acute withdrawal syndrome or PAWS) has been …
Suicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational …
Background There is ongoing controversy whether antidepressant use alters suicide risk in
adults with depression and other treatment indications. Methods Systematic review of …
adults with depression and other treatment indications. Methods Systematic review of …
[HTML][HTML] From treatment of mental disorders to the treatment of difficult life situations: a hypothesis and rationale
T Bergström - Medical Hypotheses, 2023 - Elsevier
The group-level symptom-reduction model of mental health care emphasizes predetermined
treatment guidelines for those mental and social difficulties that are diagnosable as mental …
treatment guidelines for those mental and social difficulties that are diagnosable as mental …