Stem cells can generate a diversity of cell types during development, regeneration and adult
tissue homeostasis. Differentiation changes not only the cell fate in terms of gene expression …

Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

Many cellular activities, such as cell migration, cell division, phagocytosis, and exo-
endocytosis, generate and are regulated by membrane tension gradients. Membrane …

Graphs are powerful tools to model manufacturing systems and scheduling problems. The
complexity of these systems and their scheduling problems has been substantially …

Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation
on the cell surface, which is the primary function of the endocytosis machinery. Using super …

Phosphatidylinositol 4, 5-bisphosphate (PIP2) is an important molecule located at the inner
leaflet of cell membrane, where it serves as anchoring sites for a cohort of membrane …

The actin-rich cortex plays a fundamental role in many cellular processes. Its architecture
and molecular composition vary across cell types and physiological states. The full …

Clathrin-mediated endocytosis (CME) robustness under elevated membrane tension is
maintained by actin assembly–mediated force generation. However, whether more actin …

Phagocytosis is a critical immune function for infection control and tissue homeostasis.
During phagocytosis, pathogens are internalized and degraded in phagolysosomes. For …

Labeled ammonium cations with pKa∼ 7.4 accumulate in acidic organelles because they
can be neutralized transiently to cross the membrane at cytosolic pH 7.2 but not at their …