Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation

AL Silva, C Peres, J Conniot, AI Matos, L Moura… - Seminars in …, 2017 - Elsevier
Nanotechnology-based strategies can dramatically impact the treatment, prevention and
diagnosis of a wide range of diseases. Despite the unprecedented success achieved with …

[HTML][HTML] Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses

L Shen, S Tenzer, W Storck, D Hobernik… - Journal of Allergy and …, 2018 - Elsevier
Background Nanoparticle (NP)–based vaccines are attractive immunotherapy tools because
of their capability to codeliver antigen and adjuvant to antigen-presenting cells. Their cellular …

Recent advances in the use of nanoparticles for allergen‐specific immunotherapy

H Pohlit, I Bellinghausen, H Frey, J Saloga - Allergy, 2017 - Wiley Online Library
The number of patients suffering from allergic asthma and rhinoconjunctivitis has increased
dramatically within the last decades. Allergen‐specific immunotherapy (AIT) is the only …

Immunomodulatory Effects of Subacute Inhalation Exposure to Copper Oxide Nanoparticles in House Dust Mite-Induced Asthma

S Areecheewakul, A Adamcakova-Dodd… - ACS …, 2023 - ACS Publications
It has been shown that inhalation exposure to copper oxide nanoparticles (CuO NPs) results
in pulmonary inflammation. However, immunomodulatory consequences after CuO NP …

Allergen immunotherapy: progress and future outlook

L Šošić, M Paolucci, S Flory, F Jebbawi… - Expert Review of …, 2023 - Taylor & Francis
Introduction Allergy, the immunological hypersensitivity to innocuous environmental
compounds, is a global health problem. The disease triggers, allergens, are mostly proteins …

[HTML][HTML] Recent advances in nanomaterials for asthma treatment

X Zuo, X Guo, Y Gu, H Zheng, Z Zhou, X Wang… - International Journal of …, 2022 - mdpi.com
Asthma is a chronic airway inflammatory disease with complex mechanisms, and these
patients often encounter difficulties in their treatment course due to the heterogeneity of the …

Clinical use of adjuvants in allergen-immunotherapy

L Klimek, CB Schmidt-Weber, MF Kramer… - Expert review of …, 2017 - Taylor & Francis
ABSTRACT Introduction: Allergen-specific Immunotherapy (AIT) is the only available
treatment aimed to tackle the underlying causes of allergy. The active components of …

Polyester as antigen carrier toward particulate vaccines

M Gonzalez-Miro, S Chen, ZJ Gonzaga… - …, 2019 - ACS Publications
Spherical polyhydroxyalkanoate (PHA) inclusions are naturally self-assembled inside
bacteria. These PHA beads are shell–core structures composed of a hydrophobic PHA core …

Airway epithelial-targeted nanoparticles for asthma therapy

S Kan, DM Hariyadi, C Grainge… - … of Physiology-Lung …, 2020 - journals.physiology.org
Asthma is a common chronic inflammatory disease associated with intermittent airflow
obstruction caused by airway inflammation, mucus overproduction, and bronchial …

Impact of molecular weight on the intrinsic immunogenic activity of poly (beta amino esters)

JI Andorko, KG Pineault… - Journal of Biomedical …, 2017 - Wiley Online Library
Polymeric carriers are ubiquitously studied in vaccine and drug delivery to control the
encapsulation, kinetics, and targeting of cargo. Recent research reveals many polymers can …