The Hierarchical Taxonomy of Psychopathology (HiTOP) in psychiatric practice and research
The Hierarchical Taxonomy of Psychopathology (HiTOP) has emerged out of the
quantitative approach to psychiatric nosology. This approach identifies psychopathology …
quantitative approach to psychiatric nosology. This approach identifies psychopathology …
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …
and progression and have potential to produce clinically useful biomarkers. A growing body …
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta …
substance-specific addiction risk. We report a multivariate genome-wide association meta …
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …
[HTML][HTML] Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy
G Hindley, AA Shadrin, D van der Meer… - Nature human …, 2023 - nature.com
Personality and cognitive function are heritable mental traits whose genetic foundations may
be distributed across interconnected brain functions. Previous studies have typically treated …
be distributed across interconnected brain functions. Previous studies have typically treated …
Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism
Binge eating disorder (BED) is the most common eating disorder, yet its genetic architecture
remains largely unknown. Studying BED is challenging because it is often comorbid with …
remains largely unknown. Studying BED is challenging because it is often comorbid with …
[HTML][HTML] Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
DB Rosoff, LA Mavromatis, AS Bell, J Wagner, J Jung… - Nature aging, 2023 - nature.com
The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
[HTML][HTML] CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
S Sanchez-Roige, MV Jennings, HHA Thorpe… - Translational …, 2023 - nature.com
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …
act prematurely and is associated with multiple forms of psychopathology, including …
The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates
Substance use disorders commonly co-occur with one another and with other psychiatric
disorders. They share common features including high impulsivity, negative affect, and lower …
disorders. They share common features including high impulsivity, negative affect, and lower …