Mechanisms of long noncoding RNA function in development and disease
SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …
functions. Deep sequencing recently facilitated the discovery of thousands of novel …
The long noncoding RNA Malat1: Its physiological and pathophysiological functions
Recent studies suggest that in humans, DNA sequences responsible for protein coding
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
Developmental dynamics of lncRNAs across mammalian organs and species
Although many long noncoding RNAs (lncRNAs) have been identified in human and other
mammalian genomes, there has been limited systematic functional characterization of these …
mammalian genomes, there has been limited systematic functional characterization of these …
Technological developments in lncRNA biology
S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets
Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
Single-cell RNA-seq analysis of mouse preimplantation embryos by third-generation sequencing
The development of next generation sequencing (NGS) platform-based single-cell RNA
sequencing (scRNA-seq) techniques has tremendously changed biological researches …
sequencing (scRNA-seq) techniques has tremendously changed biological researches …
[HTML][HTML] Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
A Mahpour, AC Mullen - JHEP Reports, 2021 - Elsevier
Long non-coding RNAs (lncRNAs) are important biological mediators that regulate
numerous cellular processes. New experimental evidence suggests that lncRNAs play …
numerous cellular processes. New experimental evidence suggests that lncRNAs play …
Long non-coding RNAs: at the heart of cardiac dysfunction?
During the past decade numerous studies highlighted the importance of long non-coding
RNAs (lncRNAs) in orchestrating cardiovascular cell signaling. Classified only by a …
RNAs (lncRNAs) in orchestrating cardiovascular cell signaling. Classified only by a …
miRNAs and lncRNAs as novel therapeutic targets to improve cancer immunotherapy
Simple Summary Cancer onset and progression are promoted by high deregulation of the
immune system. Recently, major advances in molecular and clinical cancer immunology …
immune system. Recently, major advances in molecular and clinical cancer immunology …
“Cat's Cradling” the 3D genome by the act of LncRNA transcription
There is growing evidence that transcription and nuclear organization are tightly linked. Yet,
whether transcription of thousands of long noncoding RNAs (lncRNAs) could play a role in …
whether transcription of thousands of long noncoding RNAs (lncRNAs) could play a role in …