Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly
affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact
causative mechanisms are still under intense investigation. Several lines of evidence …

Background We investigated whether a panel of 12 potential novel biomarkers consisting of
proteins involved in synapse functioning and immunity would be able to distinguish patients …

Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington's disease
(HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates …

Alzheimer's disease is a progressive neurodegenerative disorder that leads to dementia
mainly among the elderly. This disease is characterized by the presence in the brain of …

In this study, the human cerebrospinal fluid (CSF) proteome was mapped using three
different strategies prior to Orbitrap LC-MS/MS analysis: SDS-PAGE and mixed mode …

The field of proteomics is undergoing rapid development in a number of different areas
including improvements in mass spectrometric platforms, peptide identification algorithms …

Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer's disease (AD), but the
early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical …

Background Alzheimer's disease (AD) is the leading cause of dementia affecting greater
than 26 million people worldwide. Although cerebrospinal fluid (CSF) levels of Aβ 42, tau …

Purpose This study is part of a larger effort aiming to expand the knowledge of brain‐
enriched proteins in human cerebrospinal fluid (CSF) and to provide novel insight into the …