Maturity-onset diabetes of the young, or MODY-monogenic diabetes, is a not-so-rare
collection of inherited disorders of non-autoimmune diabetes mellitus that remains …

N-glycosylation is a frequent modification of proteins, essential for all domains of life. N-
glycan biosynthesis is a dynamic, complex, non-templated process, wherein specific …

Purpose Identifying rare genetic causes of common diseases can improve diagnostic and
treatment strategies, but incurs high costs. We tested whether individuals with common …

Maturity onset diabetes of the young (MODY) is the most common form of monogenic
diabetes and is currently believed to have 14 subtypes. While much is known about the …

Background Monogenic diabetes presents opportunities for precision medicine but is
underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria …

ABSTRACT Introduction Type 2 diabetes (T2D) is increasingly prevalent and associated
with increased risk for cardiovascular and renal disease. After lifestyle modification …

Abstract Type 2 diabetes (T2D) is caused by an inherited predisposition to pancreatic islet β-
cell failure, which is manifested under cellular stress induced by metabolic overload. The …

The discovery of the insulin hormone over 100 years ago, and its subsequent therapeutic
application, marked a key landmark in the history of medicine and medical research. The …

Neonatal diabetes mellitus (NDM) is noted as a genetic, heterogeneous, and rare disease in
infants. NDM occurs due to a single-gene mutation in neonates. A common source for …

Maturity-onset diabetes of the young (MODY) comprises a heterogeneous group of
monogenic disorders characterized by primary defect in pancreatic β-cell function, early …