Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to
orchestrate their expansion, functional polarization and effector activity in non-lymphoid …

Dendritic-cells (DCs) have received considerable attention as potential targets for the
development of anticancer vaccines. DC-based anticancer vaccination relies on patient …

Simple Summary Recent studies revealed that type-2 conventional dendritic cells (cDC2s)
play an important role in antitumor immunity by promoting cytotoxic T-cell responses and …

Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of
pathogens to stimulate a robust and appropriate immune response. To initiate responses to …

Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is
required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms …

Mechanisms of tolerance initiated in the thymus are indispensable for establishing immune
homeostasis, but they may not be sufficient to prevent tissue-specific autoimmune diseases …

During the last decades, the pleiotropic antitumor functions exerted by type I interferons
(IFNs) have become universally acknowledged, especially their role in mediating …

Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …

Background & Aims Alteration of the gut microbiota is implicated in the development of
autoimmune type 1 diabetes (T1D), as shown in humans and the nonobese diabetic (NOD) …

Last year was the 10th anniversary of Ralph Steinman's Nobel Prize awarded for his
discovery of dendritic cells (DCs), while next year brings the 50th anniversary of that …