Dendritic cells (DCs) are highly susceptible to extrinsic signals that modify the functions of
these crucial APCs. Maturation of DCs induced by diverse proinflammatory conditions …

Progression of fatty liver to non-alcoholic steatohepatitis (NASH) is a rapidly growing health
problem. The presence of inflammatory infiltrates in the liver and hepatocyte damage …

Dendritic cells (DCs) are potent antigen-presenting cells (APCs) that are essential in
mediating the body's natural and adaptive immune responses. The body can regulate the …

As a cell-based cancer vaccine, dendritic cells (DC), derived from peripheral blood
monocytes or bone marrow (BM) treated with GM-CSF (GMDC), were initially thought to …

Here we describe a new mouse model that exploits the pattern of expression of the high-
affinity IgG receptor (CD64) and allows diphtheria toxin (DT)–mediated ablation of tissue …

The development of the most successful cancer immunotherapies in solid tumors, immune-
checkpoint blockade, has focused on factors regulating T-cell activation. Until recently, the …

Protective immune responses against respiratory pathogens, such as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …

B cells have been known for their ability to present antigens to T cells for almost 40 years.
However, the precise roles of B cell antigen presentation in various immune responses are …

Although immune checkpoint blockers have yielded significant clinical benefits in patients
with different malignancies, the efficacy of these therapies is still limited. Here, we show that …

Psoriasis is a complex chronic inflammatory skin disease with unclear molecular
mechanisms. We found that the Src homology‐2 domain‐containing protein tyrosine …