Background & Aims We recently developed a heterologous therapeutic vaccination scheme
(TherVacB) comprising a particulate protein prime followed by a modified vaccinia-virus …

Activities of dendritic cells (DCs) that present tumor antigens are often suppressed in tumors.
Here we report that this suppression is induced by tumor microenvironment-derived factors …

Cross-priming was first recognized in the context of in vivo cytotoxic T lymphocyte (CTL)
responses generated against minor histocompatibility antigens induced by immunization …

The discovery of meningeal lymphatic vessels that drain the CNS has prompted new
insights into how immune responses develop in the brain. In this study, we examined how T …

Notch signaling is an evolutionarily conserved cell-to-cell signaling pathway that regulates
cellular differentiation and function across multiple tissue types and developmental stages …

Pathological changes resulting from myocardial infarction (MI) include extracellular matrix
alterations of the left ventricle, which can lead to cardiac stiffness and impair systolic and …

Summary The interleukin-6 (IL-6) membrane receptor and its circulating soluble form, sIL-
6R, can be targeted by antibody therapy to reduce deleterious immune signaling caused by …

Transcutaneous immunization (TCI) via needle-free and non-invasive drug delivery systems
is a promising approach for overcoming the current limitations of conventional parenteral …

Correct positioning of dendritic cells (DCs) is critical for efficient pathogen encounter and
antigen presentation. Epstein-Barr virus–induced gene 2 (EBI2) has been identified as a …

Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in
adults to induce adaptive immunity, but in early life are considered under-developed or …