Antigens derived from viral infection or vaccination can persist within a host for many weeks
after resolution of the infection or vaccine responses. We previously identified lymphatic …

Dendritic cells (DCs) play a pivotal role in priming adaptive immunity. However, the
involvement of DCs in controlling excessive and deleterious T cell responses remains poorly …

Background Mitochondrial transcription factor A (TFAM) is a transcription factor that
maintains mitochondrial DNA (mtDNA) stabilization and initiates mtDNA replication …

Despite> 80 years of clinical experience with coagulation factor VIII (FVIII) inhibitors,
surprisingly little is known about the in vivo mechanism of this most serious complication of …

Abstract System lupus erythematosus (SLE) is a chronic autoimmune disorder affecting
multiple organs, and persistent disease activity is associated with increased morbidity and …

Dendritic cells (DCs) play a critical role in controlling T helper 2 (Th2) cell-dependent
diseases, but the signaling mechanism that triggers this function is not fully understood. We …

Simple Summary Cancer immunotherapy has now attracted much attention because of the
recent success of immune checkpoint inhibitors. However, they are only beneficial in a …

To specifically tailor immune responses to a given pathogenic threat, dendritic cells (DC) are
highly heterogeneous and comprise many specialized subtypes, including conventional DC …

For most frequent respiratory viruses, there is an urgent need for a universal influenza
vaccine to provide cross-protection against intra-and heterosubtypes. We previously …

Eosinophil infiltration, a hallmark of allergic asthma, is essential for type 2 immune
responses. How the initial eosinophil recruitment is regulated by lung dendritic cell (DC) …