Recent genomic studies have identified novel recurrent somatic mutations in patients with
myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic …

A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

DNA methylation is a repressive epigenetic modification that is essential for development,
exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA …

Epigenetic reprogramming consists of global changes in DNA methylation and histone
modifications. In mammals, epigenetic reprogramming is primarily associated with sexual …

DNA methylation is an epigenetic modification that plays a crucial role in normal mammalian
development, retrotransposon silencing, and cellular reprogramming. Although methylation …

Alternative splicing (AS) contributes to proteome diversity. As splicing occurs
cotranscriptionally, epigenetic determinants such as DNA methylation likely play a part in …

Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …

Unlocking Mendelian disease using exome sequencing | Genome Biology Skip to main
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While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …