[HTML][HTML] Parenteral ready-to-use fixed-dose combinations including NSAIDs with paracetamol or metamizole for multimodal analgesia—approved products and …

F Silva, G Costa, F Veiga, C Cardoso… - Pharmaceuticals, 2023 - mdpi.com
The combination of non-steroidal anti-inflammatory drugs (NSAIDs) with non-opioid
analgesics is common in clinical practice for the treatment of acute painful conditions like …

Research progress in the pharmacological activities, toxicities, and pharmacokinetics of sophoridine and its derivatives

Q Tang, Y Liu, X Peng, B Wang, F Luan… - Drug Design …, 2023 - Taylor & Francis
Sophoridine is a natural quinolizidine alkaloid and a bioactive ingredient that can be
isolated and identified from certain herbs, including Sophora flavescens Alt, Sophora …

[HTML][HTML] Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways

F Das Chagas Pereira de Andrade, AN Mendes - Scientific reports, 2020 - nature.com
Chronic inflammation is triggered by numerous diseases such as osteoarthritis, Crohn's
disease and cancer. The control of the pro-inflammatory process can prevent, mitigate …

[HTML][HTML] Aprepitant inhibits JNK and p38/MAPK to attenuate inflammation and suppresses inflammatory pain

Y Yang, W Zhou, X Xu, X Ge, F Wang… - Frontiers in …, 2022 - frontiersin.org
Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized
sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely …

[HTML][HTML] Activation of PPAR-γ induces macrophage polarization and reduces neutrophil migration mediated by heme oxygenase 1

HB Abdalla, MH Napimoga, AH Lopes… - International …, 2020 - Elsevier
Natural or synthetic ligands for peroxisome proliferator-activated receptor gamma (PPAR-γ)
represent an interesting tool for pharmacological interventions to treat inflammatory …

Photodissociation of nitric oxide from designed ruthenium nitrosyl complex: Studies on wound healing and antibacterial activity

S Singh, GR Navale, M Mahale, VK Chaudhary… - Nitric Oxide, 2022 - Elsevier
A photoactivable NO releasing complex [Ru (L 1-2)(PPh 3)(NO) Cl 2](PF 6)(1a) have been
synthesized by complex [RuL 1-2 (PPh 3) 2 Cl 2](1). Newly designed bidentate ligands, ie, 4 …

Isolation and identification of anti-inflammatory and analgesic polysaccharides from Coix seed (Coix lacryma-jobi L.var. Ma-yuen (Roman.) Stapf)

Y Sui, D Xu - Natural Product Research, 2022 - Taylor & Francis
Coix seed is a nutrient-rich food and traditional Chinese medicine with anti-inflammatory
and analgesic properties. Polysaccharides from Coix seed have been rarely investigated for …

[HTML][HTML] S-Nitroso-L-Cysteine stereoselectively blunts the deleterious effects of fentanyl on breathing while augmenting antinociception in freely-moving rats

PM Getsy, SM Baby, RB Gruber, B Gaston… - Frontiers in …, 2022 - frontiersin.org
Endogenous and exogenously administered S-nitrosothiols modulate the activities of central
and peripheral systems that control breathing. We have unpublished data showing that the …

Qianghuo Shengshi decoction exerts anti-inflammatory and analgesic via MAPKs/CREB signaling pathway

N Hu, C Wang, B Wang, L Wang, J Huang… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Traditional Chinese Medicine Qianghuo
Shengshi decoction (QSD) is widely used in the treatment of nervous headache, rheumatoid …

Research advances in the clinical application of esketamine

XX Zhang, NX Zhang, DX Liu, J Ding, YN Zhang… - Ibrain, 2022 - Wiley Online Library
Esketamine is dextrorotatory ketamine, which is an enantiomer of ketamine. Compared with
ketamine, it has the advantages of a fast metabolism, fewer side effects, and strong …