The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses
GA Soliman - Nutrients, 2013 - mdpi.com
The mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved
serine/threonine kinase which is a member of the PI3K related kinase (PIKK) family. mTOR …
serine/threonine kinase which is a member of the PI3K related kinase (PIKK) family. mTOR …
Aberrant transcription factors in the cancers of the pancreas
Transcription factors (TFs) are essential for proper activation of gene during the process of
organogenesis, differentiation, lineage specificity. Reactivation or dysregulation of TFs …
organogenesis, differentiation, lineage specificity. Reactivation or dysregulation of TFs …
New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations
HA Mahdy, H Elkady, MS Taghour… - Future Medicinal …, 2023 - Taylor & Francis
Background: VEGFR-2 is one of the most effective targets in cancer treatment. Aim: The
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …
Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations
Vascular endothelial cell proliferation and angiogenesis are all crucially impacted by
Endothelial Growth Factor Receptor-2 (VEGFR-2). Its expression is significantly boosted …
Endothelial Growth Factor Receptor-2 (VEGFR-2). Its expression is significantly boosted …
Exploring the anticancer properties of a new nicotinamide analogue: Investigations into in silico analysis, antiproliferative effects, selectivity, VEGFR-2 inhibition …
Background This study focuses on the development and evaluation of (E)-N-(3-(1-(2-(4-
bromobenzoyl) hydrazono) ethyl) phenyl) nicotinamide (BHEPN) as a potential inhibitor of …
bromobenzoyl) hydrazono) ethyl) phenyl) nicotinamide (BHEPN) as a potential inhibitor of …
New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors
Although previously considered rare, recent epidemiological studies have revealed that the
incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic …
incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic …
Localization of sunitinib, its metabolites and its target receptors in tumour‐bearing mice: a MALDI‐MS imaging study
Background and Purpose The clinical effects of anti‐angiogenic agents remain
controversial. Therefore, elucidating the pharmacological properties of these compounds is …
controversial. Therefore, elucidating the pharmacological properties of these compounds is …
Unlocking the synthetic approaches and clinical application of approved small-molecule drugs for gastrointestinal cancer treatment: A comprehensive exploration
XJ Li, P Nie, P Herdewijn, JG Sun - European Journal of Medicinal …, 2023 - Elsevier
Gastrointestinal (GI) cancers encompass a group of malignancies affecting the digestive
system, including the stomach, esophagus, liver, colon, rectum and pancreas. These …
system, including the stomach, esophagus, liver, colon, rectum and pancreas. These …
Everolimus in the treatment of patients with advanced pancreatic neuroendocrine tumors: latest findings and interpretations
E Liu, P Marincola, K Öberg - Therapeutic advances in …, 2013 - journals.sagepub.com
Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms with
various clinical presentations. More than half of patients present with so-called …
various clinical presentations. More than half of patients present with so-called …
RTK/ERK pathway under natural selection associated with prostate cancer
Y Chen, X Xin, J Li, J Xu, X Yu, T Li, Z Mo, Y Hu - PLoS One, 2013 - journals.plos.org
Prostate cancer (PCa) is a global disease causing large numbers of deaths every year.
Recent studies have indicated the RTK/ERK pathway might be a key pathway in the …
Recent studies have indicated the RTK/ERK pathway might be a key pathway in the …