The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses
A Labani-Motlagh, M Ashja-Mahdavi… - Frontiers in …, 2020 - frontiersin.org
The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …
Tumour-infiltrating lymphocytes: from prognosis to treatment selection
K Brummel, AL Eerkens, M de Bruyn… - British Journal of …, 2023 - nature.com
Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity.
Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we …
Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we …
Neutrophil-to-lymphocyte ratio and mortality in the United States general population
The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood reflects the balance between
systemic inflammation and immunity and is emerging as a prognostic biomarker in many …
systemic inflammation and immunity and is emerging as a prognostic biomarker in many …
Tumour-associated neutrophils in patients with cancer
ME Shaul, ZG Fridlender - Nature reviews Clinical oncology, 2019 - nature.com
The role and importance of neutrophils in cancer has become increasingly apparent over
the past decade. Neutrophils accumulate in the peripheral blood of patients with cancer …
the past decade. Neutrophils accumulate in the peripheral blood of patients with cancer …
Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis
We use deep transfer learning to quantify histopathological patterns across 17,355
hematoxylin and eosin-stained histopathology slide images from 28 cancer types and …
hematoxylin and eosin-stained histopathology slide images from 28 cancer types and …
Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors
We investigated the role of chemokines in regulating T cell accumulation in solid tumors.
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …
The current landscape of CAR T-cell therapy for solid tumors: Mechanisms, research progress, challenges, and counterstrategies
A Daei Sorkhabi, L Mohamed Khosroshahi… - Frontiers in …, 2023 - frontiersin.org
The successful outcomes of chimeric antigen receptor (CAR) T-cell therapy in treating
hematologic cancers have increased the previously unprecedented excitement to use this …
hematologic cancers have increased the previously unprecedented excitement to use this …
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen
exposure, where they elicit rapid and robust protective immune responses,. However, the …
exposure, where they elicit rapid and robust protective immune responses,. However, the …
Teaching an old dog new tricks: next-generation CAR T cells
N Tokarew, J Ogonek, S Endres… - British journal of …, 2019 - nature.com
Adoptive T cell therapy (ACT) refers to the therapeutic use of T cells. T cells genetically
engineered to express chimeric antigen receptors (CAR) constitute the most clinically …
engineered to express chimeric antigen receptors (CAR) constitute the most clinically …
Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells
Tumours have developed strategies to interfere with most steps required for anti-tumour
immune responses. Although many populations contribute to anti-tumour responses, tumour …
immune responses. Although many populations contribute to anti-tumour responses, tumour …