The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), have
fundamental roles in excitable tissues by facilitating rapid transmission of action potentials …

Pannexin (PANX) family proteins form large-pore channels that mediate purinergic
signaling. We analyzed the cryo-EM structures of human PANX1 in lipid nanodiscs to …

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …

Tumours are complex systems formed by cellular (malignant, immune, and endothelial cells,
fibroblasts) and acellular components (extracellular matrix (ECM) constituents and secreted …

COVID-19 public health protocols have altered children's daily routines, limiting their
physical activity opportunities. The purpose of this study was to examine how the COVID-19 …

Connexins and integrins, the two structurally and functionally distinct families of
transmembrane proteins, have been shown to be inter-connected by various modes of cross …

Under physiological conditions, microglia adopt a resting phenotype associated with the
production of anti-inflammatory and neurotrophic factors. In response to a wide variety of …

Loss of connexin-mediated cell-cell communication is a hallmark of breast cancer
progression. Pannexin1 (PANX1), a glycoprotein that shares structural and functional …

Since their characterization more than five decades ago, gap junctions and their structural
proteins—the connexins—have been associated with cancer cell growth. During that period …