Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …

Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to
environmental stresses, its contributions in organ transplantation have not been …

Plasma insulin clearance is an important determinant of plasma insulin concentration. In this
review, we provide an overview of the factors that regulate insulin removal from plasma and …

ABSTRACT CEACAM1 is an extensively studied cell surface molecule with established
functions in multiple cancer types, as well as in various compartments of the immune system …

Aims/hypothesis There is growing evidence that fruit polyphenols exert beneficial effects on
the metabolic syndrome, but the underlying mechanisms remain poorly understood. In the …

FK506-binding protein-51 (FKBP51) is a molecular cochaperone recently shown to be a
positive regulator of peroxisome proliferator-activated receptor (PPAR) γ, the master …

There is compelling evidence that developmental exposure to toxic metals increases risk for
obesity and obesity-related morbidity including cardiovascular disease and type 2 diabetes …

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a
transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells …

Both genetic and lifestyle factors contribute to the risk of non-alcoholic steatohepatitis
(NASH). Additionally, epigenetic modifications may also play a key role in the pathogenesis …