Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

With the success of immune checkpoint inhibitors (ICIs), significant progress has been made
in the field of cancer immunotherapy. Despite the long-lasting outcomes in responders, the …

For tumors to progress efficiently, cancer cells must overcome barriers of oxidative stress.
Although dietary antioxidant supplementation or activation of endogenous antioxidants by …

Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Activation of the tumor and stromal cell-driven angiogenic program is one of the first
requirements in the tumor ecosystem for growth and dissemination. The understanding of …

Tumors use several strategies to evade the host immune response, including creation of an
immune-suppressive and hostile tumor environment. Tissue hypoxia due to inadequate …

Several lines of evidence indicate that during transformation epithelial cancer cells can
acquire mesenchymal features via a process called epithelial‐to‐mesenchymal transition …

Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between
glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis …