Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

The field of nutritional psychiatry has generated observational and efficacy data supporting a
role for healthy dietary patterns in depression onset and symptom management. To guide …

Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

The extent to which neurogenesis occurs in adult primates remains controversial. In this
study, using an optimized single-cell RNA sequencing pipeline, we profiled 207,785 cells …

Alzheimer's disease (AD) is characterized by the accumulation of the tau protein in neurons,
neurodegeneration and memory loss. However, the role of non-neuronal cells in this chain …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders.
The hippocampus is a key target for novel therapeutics, playing an important role in …

Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …