Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies
Bacterial cells require DNA segregation machinery to properly distribute a genome to both
daughter cells upon division. The most common system involved in chromosome and …
daughter cells upon division. The most common system involved in chromosome and …
VirB, a transcriptional activator of virulence in Shigella flexneri, uses CTP as a cofactor
VirB is a transcriptional activator of virulence in the gram-negative bacterium Shigella
flexneri encoded by the large invasion plasmid, pINV. It counteracts the transcriptional …
flexneri encoded by the large invasion plasmid, pINV. It counteracts the transcriptional …
Molecular switching of a DNA-sliding clamp to a repressor mediates long-range gene silencing
TC McLean, F Balaguer-Perez, J Chandanani… - bioRxiv, 2024 - biorxiv.org
Long-range gene regulation is rare in bacteria and is confined to the classical DNA looping
model. Here, we use a combination of biophysical approaches, including X-ray …
model. Here, we use a combination of biophysical approaches, including X-ray …
Assembly of a segrosome by a CTP-independent ParB-like protein
KV Sukhoverkov, F Balaguer-Perez, C Aicart-Ramos… - bioRxiv, 2024 - biorxiv.org
The ATP-and CTP-dependent ParA-ParB-parS segrosome is a macromolecular complex
that segregates chromosomes/plasmids in most bacterial species. CTP binding and …
that segregates chromosomes/plasmids in most bacterial species. CTP binding and …