Mendelian randomization (MR) studies typically assess the pathogenic relevance of
environmental exposures or disease biomarkers, using genetic variants that instrument …

Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and
blood pressure by promoting renal sodium and water excretion and stimulating vasodilation …

We examined the association of common variants at the NPPA-NPPB locus with circulating
concentrations of the natriuretic peptides, which have blood pressure–lowering properties …

OBJECTIVE Natriuretic peptides (NPs) have been characterized as vascular hormones that
regulate vascular tone via guanylyl cyclase (GC), cyclic GMP (cGMP), and cGMP-dependent …

Background: Circulating B-type natriuretic peptide (BNP) concentrations strongly predict
mortality in patients with heart failure (HF). Both cardiac and extracardiac stimuli influence …

(BNP), and C-type natriuretic peptide (CNP) are the known members of the mammalian
natriuretic peptide system. The discovery of natriuretic peptides (NPs) dates back to 1981 …

The obesity pandemic is closely related to hypertension and metabolic syndrome. Visceral
adipose tissue plays a key role in the metabolic and cardiovascular complications of being …

In the 30 years since the identification of the natriuretic peptides, their involvement in
regulating fluid and blood pressure has become firmly established. Data indicating a role for …

Atrial natriuretic peptide (ANP) is a cardiac hormone with pleiotropic cardiovascular and
metabolic properties including vasodilation, natriuresis and suppression of the renin …

Natriuretic peptides (NPs) are a group of peptide-hormones mainly secreted from the heart,
signaling via c-GMP coupled receptors. NP are well known for their renal and cardiovascular …