Therapeutic implications of targeting pyroptosis in Cardiac-related etiology of heart failure

O Habimana, OM Salami, J Peng, GH Yi - Biochemical pharmacology, 2022 - Elsevier
Heart failure remains a considerable clinical and public health problem, it is the dominant
cause of death from cardiovascular diseases, besides, cardiovascular diseases are one of …

[HTML][HTML] Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats

B Toto, A Refosco, M O'Keeffe, ØH Barkhald… - Toxicology Letters, 2022 - Elsevier
Microplastic particles are ubiquitous in the environment. However, little is known about their
uptake and effects in humans or mammalian model organisms. Here, we studied the effects …

Di (2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

L Chen, M Qi, L Zhang, F Yu, D Tao… - Environmental …, 2023 - Wiley Online Library
Abstract Di (2‐ethylhexyl) phthalate (DEHP) is a plasticizer and an endocrine disruptor.
Microplastics (MPs) are pathogenic small plastic particles and abundant in the aqueous …

Microplastics and Oxidative Stress—Current Problems and Prospects

K Kadac-Czapska, J Ośko, E Knez, M Grembecka - Antioxidants, 2024 - mdpi.com
Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted
considerable attention from the scientific community and the general public, as they threaten …

[HTML][HTML] An Emerging Role of Micro-and Nanoplastics in Vascular Diseases

SE Lee, HK Yoon, DY Kim, TS Jeong, YS Park - Life, 2024 - mdpi.com
Vascular diseases are the leading causes of death worldwide, and they are attributable to
multiple pathologies, such as atherosclerosis, diabetes, and chronic obstructive pulmonary …

[HTML][HTML] Efficient extraction of small microplastic particles from rat feed and feces for quantification

B Toto, A Refosco, J Dierkes, T Kögel - Heliyon, 2023 - cell.com
To date, microplastic is ubiquitously encountered in the environment. Studies analyzing
microplastic in terrestrial ecosystems, including animal feces and feed, are few. Microplastic …

LncRNA M iat knockdown protects against pirarubicin‐induced cardiotoxicity by targeting miRNA‐129‐1‐3p

P Huang, W Zhang, J Ji, J Ma, H Cheng… - Environmental …, 2023 - Wiley Online Library
Pirarubicin (THP) is a widely used antitumor drug in clinical practice, but its cardiotoxicity
limits its use. The aim of this study was to investigate the protective effect and mechanism of …

[HTML][HTML] Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis

W Liu, B Zhang, Q Yao, X Feng, T Shen… - Frontiers in Public …, 2023 - frontiersin.org
Micro/nano-plastics (MNPs) are considered a heterogeneous class of environmental
contaminants that cause multiple toxic effects on biological species. As the commonly used …

Natural swietenine attenuates diabetic nephropathy by regulating the NF‐κB/NLRP3/Caspase‐1 signaling pathways: In vivo and in vitro study

J Duan, L He, W Deng, M Lu, Y Zhai… - Environmental …, 2022 - Wiley Online Library
Abstract Swietenine (Swi), isolated from Swietenia macrophylla King ameliorates
inflammation and oxidative stress, and diabetic nephropathy has a close connection with …

The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis

Z Song, H Wu, X Fang, X Feng, L Zhou - Frontiers in Pharmacology, 2024 - frontiersin.org
Background Polystyrene microplastics (PS-MPs) exhibit multi-target, multi-dimensional,
chronic, and low toxicity to the cardiovascular system. They enter the bloodstream through …