Numerous studies of ecological genetics have found that alleles contributing to local
adaptation sometimes cluster together, forming “genomic islands of divergence.” Divergence …

Our basic question is: Given a collection of DNA sequences, what underlying forces are
responsible for the observed patterns of variability? To approach this question we introduce …

Abstract The Neo‐Darwinian concept of natural selection is plausible when one assumes a
straightforward causation of phenotype by genotype. However, such simple 1: 1 mapping …

There is increasing interest in nonrodent translational models for the study of human
disease. The pig, in particular, serves as a useful animal model for the study of …

Centromeres direct chromosome inheritance, but in multicellular organisms their positions
on chromosomes are primarily specified epigenetically rather than by a DNA sequence. The …

Compared with other mammals, the genomes of humans and other primates show an
enrichment of large, interspersed segmental duplications (SDs) with high levels of sequence …

A comprehensive survey of a rapidly expanding field of combinatorial optimization,
mathematically oriented but offering biological explanations when required. From one cell to …

Background The human genome is highly organized in the three-dimensional nucleus.
Chromosomes fold locally into topologically associating domains (TADs) defined by …

Detailed linkage and recombination rate maps are necessary to use the full potential of
genome sequencing and population genomic analyses. We used a custom collared …

Background Patterns of genetic and genomic variance are informative in inferring population
history for human, model species and endangered populations. Results Here the genome …