Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Emerging roles of cells and molecules of innate immunity in Alzheimer's disease

B Tamburini, GD Badami, MP La Manna… - International journal of …, 2023 - mdpi.com
The inflammatory response that marks Alzheimer's disease (neuroinflammation) is
considered a double-edged sword. Microglia have been shown to play a protective role at …

Astrocyte involvement in blood–brain barrier function: a critical update highlighting novel, complex, neurovascular interactions

DR Manu, M Slevin, L Barcutean, T Forro… - International Journal of …, 2023 - mdpi.com
Neurological disorders have been linked to a defective blood–brain barrier (BBB), with
dysfunctions triggered by stage-specific disease mechanisms, some of these being …

Astrocyte metabolism and signaling pathways in the CNS

Y Zhang, Y Qi, Y Gao, W Chen, T Zhou… - Frontiers in …, 2023 - frontiersin.org
Astrocytes comprise half of the cells in the central nervous system and play a critical role in
maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated …

Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier

G Schiera, CM Di Liegro, G Schirò, G Sorbello… - Cells, 2024 - mdpi.com
The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …

Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain

M Eisenbaum, A Pearson, C Ortiz, M Koprivica… - Experimental …, 2024 - Elsevier
Repetitive mild traumatic brain injuries (r-mTBI) sustained in the military or contact sports
have been associated with the accumulation of extracellular tau in the brain, which may …

How S100B crosses brain barriers and why it is considered a peripheral marker of brain injury

V Gayger-Dias, AFK Vizuete… - Experimental …, 2023 - journals.sagepub.com
S100B is a 21-kDa protein that is produced and secreted by astrocytes and widely used as a
marker of brain injury in clinical and experimental studies. The majority of these studies are …

Neuronal conversion from glia to replenish the lost neurons

S Liang, J Zhou, X Yu, S Lu, R Liu - Neural Regeneration …, 2024 - journals.lww.com
Neuronal injury, aging, and cerebrovascular and neurodegenerative diseases such as
cerebral infarction, Alzheimer's disease, Parkinson's disease, frontotemporal dementia …

[HTML][HTML] Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model

M Ivanova, I Belaya, N Kucháriková… - Neurobiology of …, 2024 - Elsevier
Integrins are receptors that have been linked to various brain disorders, including
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin …

Combined Catalpol and Tetramethylpyrazine Promote Axonal Plasticity in Alzheimer's Disease by Inducing Astrocytes to Secrete Exosomes Carrying CDK5 mRNA …

H Chen, C Deng, Z Meng, M Zhu, R Yang, J Yuan… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is a common progressive degenerative disease of the central
nervous system in aging populations. This study aimed to investigate the effects of combined …