Functionalized nanomaterials capable of crossing the blood–brain barrier
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …
regulates exchanges between the central nervous system parenchyma and blood vessels …
Emerging roles of cells and molecules of innate immunity in Alzheimer's disease
B Tamburini, GD Badami, MP La Manna… - International journal of …, 2023 - mdpi.com
The inflammatory response that marks Alzheimer's disease (neuroinflammation) is
considered a double-edged sword. Microglia have been shown to play a protective role at …
considered a double-edged sword. Microglia have been shown to play a protective role at …
Astrocyte involvement in blood–brain barrier function: a critical update highlighting novel, complex, neurovascular interactions
Neurological disorders have been linked to a defective blood–brain barrier (BBB), with
dysfunctions triggered by stage-specific disease mechanisms, some of these being …
dysfunctions triggered by stage-specific disease mechanisms, some of these being …
Astrocyte metabolism and signaling pathways in the CNS
Y Zhang, Y Qi, Y Gao, W Chen, T Zhou… - Frontiers in …, 2023 - frontiersin.org
Astrocytes comprise half of the cells in the central nervous system and play a critical role in
maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated …
maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated …
Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier
G Schiera, CM Di Liegro, G Schirò, G Sorbello… - Cells, 2024 - mdpi.com
The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain
M Eisenbaum, A Pearson, C Ortiz, M Koprivica… - Experimental …, 2024 - Elsevier
Repetitive mild traumatic brain injuries (r-mTBI) sustained in the military or contact sports
have been associated with the accumulation of extracellular tau in the brain, which may …
have been associated with the accumulation of extracellular tau in the brain, which may …
How S100B crosses brain barriers and why it is considered a peripheral marker of brain injury
V Gayger-Dias, AFK Vizuete… - Experimental …, 2023 - journals.sagepub.com
S100B is a 21-kDa protein that is produced and secreted by astrocytes and widely used as a
marker of brain injury in clinical and experimental studies. The majority of these studies are …
marker of brain injury in clinical and experimental studies. The majority of these studies are …
Neuronal conversion from glia to replenish the lost neurons
S Liang, J Zhou, X Yu, S Lu, R Liu - Neural Regeneration …, 2024 - journals.lww.com
Neuronal injury, aging, and cerebrovascular and neurodegenerative diseases such as
cerebral infarction, Alzheimer's disease, Parkinson's disease, frontotemporal dementia …
cerebral infarction, Alzheimer's disease, Parkinson's disease, frontotemporal dementia …
[HTML][HTML] Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model
Integrins are receptors that have been linked to various brain disorders, including
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin …
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin …
Combined Catalpol and Tetramethylpyrazine Promote Axonal Plasticity in Alzheimer's Disease by Inducing Astrocytes to Secrete Exosomes Carrying CDK5 mRNA …
H Chen, C Deng, Z Meng, M Zhu, R Yang, J Yuan… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is a common progressive degenerative disease of the central
nervous system in aging populations. This study aimed to investigate the effects of combined …
nervous system in aging populations. This study aimed to investigate the effects of combined …