[HTML][HTML] Efficacy and safety of inclisiran a newly approved FDA drug: A systematic review and pooled analysis of available clinical studies

AFG Cicero, F Fogacci, A Zambon, PP Toth… - American Heart Journal …, 2022 - Elsevier
Study objective This systematic review and meta-analysis aimed to assess the efficacy and
safety profile of treatment with inclisiran, a drug that has been recently approved by the …

Rosuvastatin and ezetimibe for the treatment of dyslipidemia and hypercholesterolemia

C Boutari, A Karagiannis, VG Athyros - Expert review of …, 2021 - Taylor & Francis
Introduction: Statins are powerful lipid-lowering agents which reduce cardiovascular (CV)–
related morbidity and mortality. However, a large proportion of patients cannot attain the …

Ursolic acid inhibits the cholesterol biosynthesis and alleviates high fat diet-induced hypercholesterolemia via irreversible inhibition of HMGCS1 in vivo

X Ma, Y Bai, K Liu, Y Han, J Zhang, Y Liu, X Hou… - Phytomedicine, 2022 - Elsevier
Background In hypercholesteremia, the concentrations of total cholesterol (TC) and low-
density lipoprotein cholesterol (LDL-C) are enhanced in serum, which is strongly associated …

[HTML][HTML] Statin medications

O Sizar, S Khare, RT Jamil, R Talati - 2017 - europepmc.org
Objectives: Identify indications for initiating statin therapy. Review contraindications for statin
therapy. Explain common and uncommon adverse effects associated with statin therapy …

Effectiveness of lipid-lowering therapy on mortality and major adverse cardiovascular event outcomes in patients undergoing percutaneous coronary intervention: a …

CJ Deng, J Yan, YY Zheng, TT Wu, Y Pan, XG Hou… - BMJ open, 2023 - bmjopen.bmj.com
Background Emergency percutaneous coronary intervention (PCI) can quickly restore
myocardial perfusion after acute coronary syndrome. Whether and which lipid-lowering …

Fixed-dose combination of rosuvastatin and ezetimibe: treating hypercholesteremia according to cardiovascular risk

V Barrios, C Escobar - Expert Review of Clinical Pharmacology, 2021 - Taylor & Francis
Introduction: Reducing low-density lipoprotein cholesterol (LDL-C) with lipid-lowering
therapies has been associated with a decrease in the frequency of cardiovascular events …

Ezetimibe and atherosclerotic cardiovascular disease: a systematic review and meta-analysis

F Omidi, M Rahmannia, AH Shahidi Bonjar… - Frontiers in …, 2023 - frontiersin.org
Introduction Individuals diagnosed with atherosclerotic cardiovascular disease (ACD) are
exposed to an increased risk of cardiovascular events. Reducing low-density lipoprotein …

Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors

DP Wang, R Zhao, HF Wang, MY Wang, WS Hu… - International Journal of …, 2023 - Elsevier
Abstract In July 2022, the World Health Organization announced monkeypox as a public
health emergency of international concern (PHEIC), and over 85,000 global cases have …

[HTML][HTML] Effects of fixed-dose combination of low-intensity rosuvastatin and ezetimibe versus moderate-intensity rosuvastatin monotherapy on lipid profiles in patients …

SA Lee, W Kim, TJ Hong, Y Ahn, MH Kim, SJ Hong… - Clinical Therapeutics, 2021 - Elsevier
Purpose We investigated whether the combination therapy of low-intensity rosuvastatin and
ezetimibe is an useful alternative to moderate-intensity rosuvastatin monotherapy in patients …

Impact of Drug-Mediated Inhibition of Intestinal Transporters on Nutrient and Endogenous Substrate Disposition… an Afterthought?

K Kharve, AS Engley, MF Paine, JA Sprowl - Pharmaceutics, 2024 - mdpi.com
A large percentage (~ 60%) of prescription drugs and new molecular entities are designed
for oral delivery, which requires passage through a semi-impervious membrane bilayer in …