Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …

Triple-negative breast cancer (TNBC) is diagnosed more frequently in younger and
premenopausal women and is highly prevalent in African American women. TNBC is a term …

Purpose Cancer is one of the leading causes of death, and thus, the scientific community
has but great efforts to improve cancer management. Among the major challenges in cancer …

The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

EGFR-mutant lung cancers responsive to reversible EGFR inhibitors (gefitinib/erlotinib)
develop acquired resistance, mediated by second-site EGFR T790M mutation in> 50% of …

The'magic bullet'concept of specifically targeting cancer cells at the same time as sparing
normal tissues is now proven, as several monoclonal antibodies and targeted small …

Background KRAS mutation status is a candidate marker for predicting survival in patients
with metastatic colorectal cancer (mCRC) treated with cetuximab (CTX). Patients and …