Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total
body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of …

Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …

An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

The WHO has recognised iron deficiency anaemia (IDA) as the most common nutritional
deficiency in the world, with 30% of the population being affected with this condition …

While patient blood management (PBM) initiatives are increasingly adopted across the
globe as part of standard of care, there is need for a clear and widely accepted definition of …

Ferumoxytol is an intravenous iron oxide nanoparticle formulation that has been approved
by the US Food and Drug Administration (FDA) for treating anemia in patients with chronic …

Iron deficiency anaemia (IDA) is a major cause of morbidity and burden of disease
worldwide. It can generally be diagnosed by blood testing and remedied by iron …

Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

Iron is an essential micronutrient for a myriad of physiological processes in the body beyond
erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure …