[HTML][HTML] Metabolomics, physical activity, exercise and health: A review of the current evidence
Physical activity (PA) and exercise are among the most important determinants of health.
However, PA is a complex and heterogeneous behavior and the biological mechanisms …
However, PA is a complex and heterogeneous behavior and the biological mechanisms …
Metabolomics in the clinic: A review of the shared and unique features of untargeted metabolomics for clinical research and clinical testing
AD Kennedy, BM Wittmann, AM Evans… - Journal of Mass …, 2018 - Wiley Online Library
Metabolomics is the untargeted measurement of the metabolome, which is composed of the
complement of small molecules detected in a biological sample. As such, metabolomic …
complement of small molecules detected in a biological sample. As such, metabolomic …
A reference map of potential determinants for the human serum metabolome
The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …
diseases, some of which are endogenously produced and some that have been taken up …
Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease
KL Bowerman, SF Rehman, A Vaughan… - Nature …, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death
globally, and manifests as a progressive inflammatory lung disease with no curative …
globally, and manifests as a progressive inflammatory lung disease with no curative …
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell
metabolism but concurrently enhances the metabolic fitness of tumor CD8+ T cells. DON …
metabolism but concurrently enhances the metabolic fitness of tumor CD8+ T cells. DON …
The fecal metabolome as a functional readout of the gut microbiome
The human gut microbiome plays a key role in human health 1, but 16S characterization
lacks quantitative functional annotation 2. The fecal metabolome provides a functional …
lacks quantitative functional annotation 2. The fecal metabolome provides a functional …
[HTML][HTML] Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
The human gut microbiome is comprised of densely colonizing microorganisms including
bacteriophages, which are in dynamic interaction with each other and the mammalian host …
bacteriophages, which are in dynamic interaction with each other and the mammalian host …
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease
Abstract Background Trimethylamine N-oxide (TMAO), a small molecule produced by the
metaorganismal metabolism of dietary choline, has been implicated in human disease …
metaorganismal metabolism of dietary choline, has been implicated in human disease …
Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a Mendelian randomisation analysis
Background Higher circulating levels of the branched-chain amino acids (BCAAs; ie,
isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but …
isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but …