As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

A study with low statistical power has a reduced chance of detecting a true effect, but it is
less well appreciated that low power also reduces the likelihood that a statistically significant …

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …

Abnormal oxidative stress is an established feature of Alzheimer's disease, but clinical trials
aiming to reduce oxidative stress have not yet proven an effective therapy for dementia …

Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …

Alzheimer′ s disease (AD) is a progressive neurodegenerative disorder that accounts for
the major cause of dementia, and the increasing worldwide prevalence of AD is a major …

Amyloid and tau aggregation are implicated in manifold neurodegenerative diseases and
serve as two signature pathological hallmarks in Alzheimer's disease (AD). Though aging is …