Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

It is commonly assumed that mitochondrial DNA (mtDNA) evolves at a faster rate than
nuclear DNA (nuDNA) in animals. This has contributed to the popularity of mtDNA as a …

We present an in silico approach for the reconstruction of complete mitochondrial genomes
of non-model organisms directly from next-generation sequencing (NGS) data …

Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the
lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response …

The life span of C. elegans can be increased via reduced function of the mitochondria;
however, the extent to which mitochondrial alteration in a single, distinct tissue may …

The memory of stresses experienced by parents can be passed on to descendants as a
forecast of the challenges to come. Here, we discovered that the neuronal mitochondrial …

The ability to respond to various intracellular and/or extracellular stresses allows the
organism to adapt to changing environmental conditions and drives evolution. It is now well …

Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but
also implicated in age-related diseases, including those that affect the metabolic and …

Mitochondria are required for numerous essential metabolic processes including the
regulation of apoptosis; therefore, proper maintenance of the mitochondrial proteome is …