Progress made in peptide-based vaccinations to induce T-cell-dependent immune
responses against cancer has invigorated the search for optimal vaccine modalities. Design …

Abundant macrophage infiltration of solid cancers commonly correlates with poor prognosis.
Tumor-promoting functions of macrophages include angiogenesis, metastasis formation …

Purpose: Cancer immunotherapy, such as vaccination, is an increasingly successful
treatment modality, but its interaction with chemotherapy remains largely undefined …

Checkpoint inhibition has established immunotherapy as a major modality of cancer
treatment. However, the success of cancer immunotherapy is still limited as immune …

Nanoparticulate formulations for synthetic long peptide (SLP)-cancer vaccines as alternative
to clinically used Montanide ISA 51-and squalene-based emulsions are investigated in this …

US11452768B2 - Combination therapy with neoantigen vaccine - Google Patents US11452768B2
- Combination therapy with neoantigen vaccine - Google Patents Combination therapy with …

Background Triple-negative breast cancer (TNBC) corresponds to approximately 20% of all
breast tumors, with a high propensity for metastasis and a poor prognosis. Because TNBC …

Peptides and peptidomimetics can function as immunomodulating agents by either blocking
the immune response or stimulating the immune response to generate tolerance …

The effectiveness of T-cell-mediated immunotherapy of cancer depends on both an optimal
immunostimulatory context of the therapy and the proper selection with respect to quality …

Immune checkpoint inhibition targeting T cells has shown tremendous promise in the
treatment of many cancer types and are now standard therapies for patients. While standard …