The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires
an urgent deployment of advanced therapeutic options available. The role of …

Over the last decade, based on the extensive development of preclinical animal studies and
clinical trials, the efficacy, and mechanisms of immunotherapy have been fully explored …

Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at
the forefront of immunotherapy for cancers of various histological types. However, such …

Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

The average age of liver transplant donors and recipients has increased over the years.
Independent of the cause of liver disease, older candidates have more comorbidities, higher …

Although the clinical development of immune checkpoint inhibitors (ICIs) therapy has
ushered in a new era of anti-tumor therapy, with sustained responses and significant …

With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

In studies of immune aging, naive T cells frequently take center stage. Describing the
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …

Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …

Resveratrol (3, 5, 4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be
present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been …