Development of In Vitro and Ex Vivo Biofilm Models for the Assessment of Antibacterial Fibrous Electrospun Wound Dressings

K Lorenz, L Preem, K Sagor, M Putrins… - Molecular …, 2023 - ACS Publications
Increasing evidence suggests that the chronicity of wounds is associated with the presence
of bacterial biofilms. Therefore, novel wound care products are being developed, which can …

In vitro Activity of Antimicrobial Wound Dressings on P. aeruginosa Wound Biofilm

EK Stuermer, I Plattfaut, M Dietrich, F Brill… - Frontiers in …, 2021 - frontiersin.org
The treatment of acute and chronic infected wounds with residing biofilm still poses a major
challenge in medical care. Interactions of antimicrobial dressings with bacterial load, biofilm …

[HTML][HTML] Pulsed low-intensity laser treatment stimulates wound healing without enhancing biofilm development in vitro

M Besser, L Schaeler, I Plattfaut, FHH Brill… - … of Photochemistry and …, 2022 - Elsevier
Objectives Treating infected or chronic wounds burdened with biofilms still is a major
challenge in medical care. Healing-stimulating factors lose their efficacy due to bacterial …

Quantitative Insights and Visualization of Antimicrobial Tolerance in Mixed-Species Biofilms

M Dittmer, FHH Brill, A Kampe, M Geffken, JD Rembe… - Biomedicines, 2023 - mdpi.com
Biofilms are a major problem in hard-to-heal wounds. Moreover, they are composed of
different species and are often tolerant to antimicrobial agents. At the same time …

Human skin biofilm model: Translational impact on swabbing and debridement

M Dietrich, M Besser, ES Debus… - Journal of Wound …, 2023 - magonlinelibrary.com
Objective: Wound biofilms are one of the greatest challenges in the therapy of hard-to-heal
(chronic) wounds, as potent antimicrobial substances fail to eradicate bacteria within short …

[HTML][HTML] Comparison of antibiofilm activity of low-concentrated hypochlorites vs polyhexanide-containing antiseptic

J Paleczny, AF Junka, P Krzyżek… - Frontiers in cellular …, 2023 - frontiersin.org
In this work, the antimicrobial/antibiofilm activity of two low-concentrated chlorine-based and
releasing solutions was investigated on a total of 78 strains of methicillin-resistant …

Culture Shock: An Investigation into the Tolerance of Pathogenic Biofilms to Antiseptics in Environments Resembling the Chronic Wound Milieu

J Paleczny, M Brożyna, B Dudek, A Woytoń… - International Journal of …, 2023 - mdpi.com
Credible assessment methods must be applied to evaluate antiseptics' in vitro activity
reliably. Studies indicate that the medium for biofilm culturing should resemble the …

Characterization of the Human Plasma Biofilm Model (hpBIOM) to Identify Potential Therapeutic Targets for Wound Management of Chronic Infections

M Dietrich, M Besser, EK Stuermer - Microorganisms, 2024 - mdpi.com
The treatment of chronic wounds still represents a major challenge in wound management.
Recent estimates suggest that 60–80% of chronic wounds are colonized by pathogenic …

Wound biofilm: A bacterial success story

EK Stuermer - Journal of Wound Management, 2023 - search.informit.org
Background Wound biofilm is one of the greatest challenges in the local therapy of chronic
wounds. In clinical practice, it becomes apparent that there are significant differences in the …

Copper-based dressing: Efficacy in a wound infection of ex vivo human skin

AD Strickland, M Ozturk, T Conti, F Tabatabaei - Tissue and Cell, 2023 - Elsevier
This study aimed to evaluate the wound healing and antibacterial effects of two experimental
copper dressings compared to a commercial silver dressing. Burn wounds were created in …