Orthodontic patients complain of pain for the first few days after insertion of appliances.
Mechanical force has been reported to produce oxidants in periodontal ligament (PDL) cells …

Experimental models of neuropathic pain (NP) typically rely on withdrawal responses to
assess the presence of pain. Reflexive withdrawal responses to a stimulus are used to …

Orthodontic force produces mechanical irritation and inflammation in the periodontium,
which is inevitably accompanied by pain. Despite its prevalence, treatment of orthodontic …

Objectives: The aim of this study was to assess whether the RGS and 2 additional
behavioral tools (composite behavior score [CBS] and burrowing) could identify pain in an …

Calcitonin-related gene peptide (CGRP) plays an important role in orofacial inflammatory
pain. The aim of this study was to determine whether periodontal CGRP contributes to …

Orthodontic pain that is induced by tooth movement is an important sequela of orthodontic
treatment and has a significant effect on patient quality of life. Studies have shown that the …

The nerve growth factor (NGF) and calcitonin gene-related peptide (CGRP) play a crucial
role in the regulation of orofacial pain. It has been demonstrated that CGRP increases …

Background Stomatitis induces severe and painful hypersensitivity to pungency and
physical contact during meals. Many studies have used anesthetized animals to examine …

Cortical excitation responding to periodontal ligament (PDL) stimulation is observed in the
rat primary somatosensory (S1), secondary somatosensory, and insular oral region of the …

Objectives: This study aimed to clarify the roles of Acid-sensing ion channel 3 (ASIC3) in
orofacial pain following experimental tooth movement. Materials and methods: Sixty male …