Invasive fungal infections continue to appear in record numbers as the
immunocompromised population of the world increases, owing partially to the increased …

Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

We have previously reported on classes of compounds that can interfere with bioassays via
a number of different mechanisms and termed such compounds Pan Assay INterference …

The high burden and growing prevalence of invasive fungal infections (IFIs), the toxicity and
interactions associated with current antifungal drugs, as well as the increasing resistance …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low
toxicity remain challenging, and obtaining such agents continues to be an active area of …

The ecstasy of discovering a new hit from screening can lead to a highly productive research
effort to discover new bioactive compounds. However, in too many cases this ecstasy is …

Highlights•Mining pharmacophore-based virtual and tangible, novel chemical spaces are
examined.•Using intelligent prediction software leads to much faster wet lab …

Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Aberrant activation of the Wnt/β‐catenin signaling circuit is associated with cancer
recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion …