[HTML][HTML] Biomolecular condensates and cancer
Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …
have been the subject of detailed genetic, biochemical, and structural studies, but only …
[HTML][HTML] Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
[HTML][HTML] MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression.
Although MYC is overexpressed in both early and metastatic disease and associated with …
Although MYC is overexpressed in both early and metastatic disease and associated with …
[HTML][HTML] Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-
invasive assays for assessing transcription factor activity are lacking. Here we develop and …
invasive assays for assessing transcription factor activity are lacking. Here we develop and …
[HTML][HTML] High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Systemic metabolic alterations associated with increased consumption of saturated fat and
obesity are linked with increased risk of prostate cancer progression and mortality, but the …
obesity are linked with increased risk of prostate cancer progression and mortality, but the …
[HTML][HTML] Epithelial–mesenchymal transition signaling and prostate cancer stem cells: emerging biomarkers and opportunities for precision therapeutics
Prostate cancers may reactivate a latent embryonic program called the epithelial–
mesenchymal transition (EMT) during the development of metastatic disease. Through EMT …
mesenchymal transition (EMT) during the development of metastatic disease. Through EMT …
Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress
Drugs that block the activity of the methyltransferase EZH2 are in clinical development for
the treatment of non-Hodgkin lymphomas harboring EZH2 gain-of-function mutations that …
the treatment of non-Hodgkin lymphomas harboring EZH2 gain-of-function mutations that …
The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer
M Pieraccioli, C Caggiano, L Mignini, C Zhong… - Nature structural & …, 2022 - nature.com
Alternative polyadenylation (APA) yields transcripts differing in their 3′-end, and its
regulation is altered in cancer, including prostate cancer. Here we have uncovered a …
regulation is altered in cancer, including prostate cancer. Here we have uncovered a …
[HTML][HTML] Post-transcriptional gene regulation by MicroRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer
RC Fernandes, J Toubia, S Townley, AR Hanson… - Cell reports, 2021 - cell.com
Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can
lead to the emergence of neuroendocrine prostate cancer (NEPC), a phenomenon …
lead to the emergence of neuroendocrine prostate cancer (NEPC), a phenomenon …
[HTML][HTML] High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
HM Itkonen, A Urbanucci, SES Martin, A Khan… - Theranostics, 2019 - ncbi.nlm.nih.gov
O-GlcNAc transferase (OGT) is overexpressed in aggressive prostate cancer. OGT modifies
intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity …
intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity …