The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Although genetics determines endocrine phenotypes, it cannot fully explain the great
variability and reversibility of the system in response to environmental changes. Evidence …

How physical force is sensed by cells and transduced into cellular signaling pathways is
poorly understood. Previously, we showed that tyrosine phosphorylation of p130Cas (Cas) …

Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor
superfamily, was initially identified in constitutively activated oncogenic fusion forms–the …

Although genetics determines endocrine phenotypes, it cannot fully explain the great
variability and reversibility of the system in response to environmental changes. Evidence …

Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …

Hepatocellular carcinoma (HCC) is one of the most common cancers with an insidious
onset, strong invasiveness, insensitivity to chemotherapy, and poor prognosis, thus makes …

Fyn is a non-receptor tyrosine kinase belonging to the Src family kinases. It has been shown
to play important roles in neuronal functions, including myelination and oligodendrocytes …

Background Radiation exerts direct antitumor effects and is widely used in clinics, but the
efficacy is severely compromised by tumor resistance. Therefore uncovering the mechanism …

Purpose Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the
sixth largest common cancer worldwide. Although surgical resection, hepatic arterial …