Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

MDA Paskeh, M Entezari, S Mirzaei, A Zabolian… - Journal of hematology & …, 2022 - Springer
Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

[HTML][HTML] Exosomes in urological diseases-biological functions and clinical applications

Q Song, H Yu, J Han, J Lv, Q Lv, H Yang - Cancer Letters, 2022 - Elsevier
Exosomes are extracellular vesicles with a variety of biological functions that exist in various
biological body fluids and exert their functions through proteins, nucleic acids, lipids, and …

miR-425-5p as an exosomal biomarker for metastatic prostate cancer

MP Rode, AH Silva, J Cisilotto, D Rosolen… - Cellular …, 2021 - Elsevier
Prostate cancer-related deaths are mostly caused by metastasis, which indicates the
importance of identifying clinical prognostic biomarkers. In this study, we evaluated the …

CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction

Q Zhang, L Chen, L Huang, H Cheng, L Wang, L Xu… - Molecular …, 2022 - Springer
Background Since angiogenesis occurs as the pathological process following myocardial
infarction to alleviate ischemia, therapeutic angiogenesis has been proposed to be a …

Extracellular vesicle RNA signaling in the liver tumor microenvironment

P Gondaliya, AA Sayyed, J Driscoll, K Patel, T Patel - Cancer letters, 2023 - Elsevier
The tumor microenvironment (TME) in liver cancers such as hepatocellular cancer (HCC)
consists of a complex milieu of liver tissue-resident cells, infiltrated immune cells, and …

Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer

D Xu, WJ Tang, YZ Zhu, Z Liu, K Yang… - International Journal …, 2022 - Taylor & Francis
Purpose To investigate the mechanism through which hyperthermia promotes exosome
secretion and drug sensitivity in adriamycin-resistant breast cancer. Materials and Methods …

[HTML][HTML] Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications

W Chang, M Li, L Song, S Miao, W Yu, J Wang - Molecular Metabolism, 2022 - Elsevier
Diabetes is a systemic disease, and its progression involves multiple organ dysfunction.
However, the exact mechanisms underlying pathological progression remain unclear. Small …

EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy

Y Ding, J Chen, S Li, JD Wren, AK Bajpai, J Wang… - Oncogene, 2023 - nature.com
Experimental studies on immunoglobulin superfamily (IgSF) member EWI2 reveal that it
suppresses a variety of solid malignant tumors including brain, lung, skin, and prostate …

Heterogeneous nuclear ribonucleoprotein A1 loads batched tumor-promoting MicroRNAs into small extracellular vesicles with the assist of caveolin-1 in A549 cells

Y Li, J Zhang, S Li, C Guo, Q Li, X Zhang… - Frontiers in cell and …, 2021 - frontiersin.org
MicroRNAs in small extracellular vesicle (sEV-miRNAs) have been widely investigated as
crucial regulated molecules secreted by tumor cells to communicate with surroundings. It is …

EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer

J Wang, JD Wren, Y Ding, J Chen, N Mittal, C Xu, X Li… - Cancer letters, 2022 - Elsevier
As a partner of tetraspanins, EWI2 suppresses glioblastoma, melanoma, and prostate
cancer; but its role in lung cancer has not been investigated. Bioinformatics analysis reveals …