Small molecule tyrosine kinase inhibitors (TKIs) are widely used as anticancer drugs
approved by US FDA. However, the toxicities of TKIs to multiple organs have greatly limited …

Adenosine is an autacoid that plays a critical role in regulating cardiac function, including
heart rate, contractility, and coronary flow. In this chapter, current knowledge of the functions …

Adenosine (Ado) accumulates in tissues under metabolic stress. On myocardial cells, the
nucleoside interacts with various receptor subtypes (A1, A3, and probably A2A and A2B) …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

Nucleoside triphosphate diphosphohydrolases (NTPDases) are a recently described family
of ectonucleotidases that differentially hydrolyze the γ and β phosphate residues of …

Background—The origin of 40% of syncope cases remains unknown even after a complete
diagnostic workup. Previous studies have suggested that ATP testing has value in selecting …

The vascular response to adenosine and its analogs is mediated by four adenosine
receptors (ARs), namely, A1, A2A, A2B, and A3. A2AARs and/or A2BARs are involved in …

The aim of this investigation was to test the hypothesis that extracellular guanosine
regulates extracellular adenosine levels. Rat preglomerular vascular smooth muscle cells …

Abstract Adenosine 5'-triphosphate (ATP) plays a critical role in intracellular metabolism and
energetics. Extracellular ATP is rapidly degraded to adenosine by ectoenzymes. Both ATP …

Abstract Adenosine 5′-triphiosphate (ATP) is released from cells under physiologic and
pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine agent …