Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Context Current literature suggests that several pathophysiological factors and mechanisms
might be responsible for the nonspecific symptom complex of overactive bladder (OAB) …

Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted
the dangers of treating pain with opioids. An alternative addiction-free strategy to …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Cough is the most common reason for patients to visit a primary care physician, yet it
remains an unmet medical need. It can be idiopathic in nature but can also be a …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …