Although their etiologies vary, tumors share a common trait: the control of an oncogenic
transcriptional program that is regulated by the interaction of the malignant cells with the …

Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …

Background Previous studies have demonstrated that inflammation-related interleukin-17 (IL-
17) signaling plays a pivotal role in the pathogenesis of non-alcoholic steatohepatitis …

To discover distinct immune responses promoting or inhibiting hepatocellular carcinoma
(HCC), we perform a three-dimensional analysis of the immune cells, correlating immune …

The opposing roles of innate and adaptive immune cells in suppressing or supporting
cancer initiation, progression, metastasis and response to therapy has been long debated …

Hepatic fibrosis (HF) is involved in aggravated wound‐healing response as chronic liver
injury. Extracellular vesicles (EVs) carrying microRNA (miR) have been reported as …

Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Interleukin 17A (IL-17A)-producing T helper 17 (Th17) cells were identified as a subset of T
helper cells that play a critical role in host defense against bacterial and fungal pathogens …

Chemokine CXC motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages
and epithelial cells, is a valid pro-inflammatory factor which performs an important role in …

Abstract IL-17-producing CD8 (Tc17) T cells have been shown to play an important role in
infection and chronic inflammation, however their implications in hepatocellular carcinoma …