Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

Abstract The Biopharmaceutics Classification System (BCS) has found widespread utility in
drug discovery, product development and drug product regulatory sciences. The …

Cocrystals have become an established and adopted approach for creating crystalline
solids with improved physical properties, but incorporating cocrystals into enabling pre …

Objectives Drug precipitation in vivo poses a significant challenge for the pharmaceutical
industry. During the drug development process, the impact of drug supersaturation or …

The low and variable oral bioavailability of poorly water soluble drugs remains a major
concern for the pharmaceutical industry. Spray congealing is an emerging technology for the …

The purpose of this work was to investigate key factors dictating the success/failure of
cyclodextrin-based solubility-enabling formulations for oral delivery of low-solubility drugs …

The aim of this study was to establish an in vitro method for evaluating the effect of
supersaturation on oral absorption of poorly water-soluble drugs in vivo. Albendazole …

The present work aimed to differentiate between in vitro dissolution profiles of ibuprofen as
input for GastroPlus™ and to see the impact on systemic exposure. In vitro dissolution …

Introduction Controlled release (CR) dosage forms comprise a wide range of technologies,
which modify the drug pharmacokinetic (PK) profile by avoiding the immediate release (IR) …