In vitro-in vivo correlations (IVIVCs) play an important role in formulation development and
drug approval. At the heart of IVIVC is deconvolution, the method of deriving an in vivo …

In a biphasic dissolution medium, the integration of the in vitro dissolution of a drug in an
aqueous phase and its subsequent partitioning into an organic phase is hypothesized to …

Dissolution has become an indispensable tool to predict the in vivo performance of dosage
form, especially in recent times, because of the increasing complexity of new drugs …

Valsartan (VST) is a poorly water-soluble drug and a P-glycoprotein (P-gp) substrate. To
enhance the dissolution and oral absorption of VST, a novel supersaturable self …

Establishing an in vitro–in vivo correlation (IVIVC) is based on the ability to develop an in
vitro dissolution test that is predictive of the in vivo performance of the drug product. A …

Drug absorption from drug products may be affected by pharmaceutical excipients and/or
food additives through different mechanisms. Chitosan is a recognized nutraceutical, with …

During formulation development, efficiently integrating in vitro dissolution testing can
significantly improve one's ability to estimate in vivo performance and aide in the selection of …

The gastrointestinal (GI) tract is one of the most popular and used routes of drug product
administration due to the convenience for better patient compliance and reduced costs to the …

The aim of this study was to develop a sensitive and discriminative in vitro–in silico model
able to simulate the in vivo performance of three fenofibrate immediate release formulations …

Purpose To develop a dose dependent version of BCS and identify a critical dose after
which the amount absorbed is independent from the dose. Methods We utilized a …