The potential use of poly (dimethylsiloxane)(PDMS) as an in vitro biomimetic analogue of
the passive drug absorption process in the human gastrointestinal tract (GI) is assessed …

To understand the sophisticated dynamic behaviors of drug elution and permeation in the
gastrointestinal tract (GIT), researchers have tried to reemerge it by employing various in …

This study aimed to kinetically analyze the nonlinear absorption and systemic exposure of
telmisartan (TEL) after oral administration to rats by using a stable isotope-IV method. Rats …

ONO-5129 is a dual agonist of peroxisome proliferator-activated receptors (PPARs) α and γ
with poor water solubility. To assess the clinical “developability” of this drug candidate, we …

口服药物制剂在胃肠道的溶出和吸收过程, 是一个连续, 动态, 同步进行的动力学过程,
影响着体内生物利用度. 药物溶出/透过同步评价技术将体外溶出模型和跨膜透过模型有机结合 …

Beschreibungen: Seit dem Paradigmenwechsel von den früher bevorzugten flüssigen
Darreichungsformen zu festen Darreichungsformen für pädiatrische Patienten sind …

Bioequivalence has also been referred to as comparative bioavailability. The concept of
bioequivalence started gaining an increased attention during the last three decades, after it …

Objectives: Mesoporous silicas (SLC) have demonstrated considerable potential to improve
bioavailability of poorly soluble drugs by facilitating rapid dissolution and generating …

Obtaining optimal oral exposure in the drug discovery process can be a challenging goal for
the discovery team, especially when the target therapy demands adequate exposure …

The partition rate of 2 model compounds, 2-naphthol (NAP) and ritonavir (RTV), across the
water-octanol (W/O) interface was determined from aqueous solutions with and without the …