Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease

G Verdile, KN Keane, VF Cruzat, S Medic… - Mediators of …, 2015 - Wiley Online Library
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

Panax ginseng and Panax quinquefolius: From pharmacology to toxicology

C Mancuso, R Santangelo - Food and Chemical Toxicology, 2017 - Elsevier
The use of Panax ginseng and Panax quinquefolius in traditional Chinese medicine dates
back to about 5000 years ago thanks to its several beneficial and healing properties. Over …

Ferulic acid: pharmacological and toxicological aspects

C Mancuso, R Santangelo - Food and Chemical Toxicology, 2014 - Elsevier
Ferulic acid (FA) belongs to the family of phenolic acids and is very abundant in fruits and
vegetables. Over the past years, several studies have shown that FA acts as a potent …

[HTML][HTML] Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain

DA Butterfield, F Di Domenico, E Barone - Biochimica et Biophysica Acta …, 2014 - Elsevier
Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

[HTML][HTML] Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals—A review

MT Lee, WC Lin, B Yu, TT Lee - Asian-Australasian journal of …, 2017 - ncbi.nlm.nih.gov
Oxidative stress suppresses animal health, performance, and production, subsequently
impacting economic feasibility; hence, maintaining and improving oxidative status especially …

Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain

R Sultana, M Perluigi, DA Butterfield - Free Radical Biology and Medicine, 2013 - Elsevier
Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

The role of type 2 diabetes in neurodegeneration

G Verdile, SJ Fuller, RN Martins - Neurobiology of disease, 2015 - Elsevier
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease

KT Liby, MB Sporn - Pharmacological reviews, 2012 - ASPET
We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …

[HTML][HTML] Interaction of aldehydes derived from lipid peroxidation and membrane proteins

S Pizzimenti, E Ciamporcero, M Daga… - Frontiers in …, 2013 - frontiersin.org
A great variety of compounds are formed during lipid peroxidation of polyunsaturated fatty
acids of membrane phospholipids. Among them, bioactive aldehydes, such as 4 …

[HTML][HTML] Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

V Calabrese, C Cornelius, AT Dinkova-Kostova… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …