Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

During the osteoarthritis (OA) process, activation of immune systems, whether innate or
adaptive, is strongly associated with low-grade systemic inflammation. This process is …

Since the progression of osteoarthritis (OA) is closely associated with synovitis and cartilage
destruction, the inhibition of inflammatory responses in synovial macrophages and reactive …

Osteoarthritis (OA) is a prevalent progressive disease that frequently coexists with obesity.
For several decades, OA was thought to be the result of ageing and mechanical stress on …

Osteoarthritis (OA) is progressive disease characterised by cartilage degradation,
subchondral bone remodelling and inflammation of the synovium. The disease is associated …

Chronic inflammation is implicated in numerous human pathologies. In particular, low-grade
inflammation is currently recognized as an important mechanism of osteoarthritis (OA), at …

Immunogenic cell death (ICDs) has gained increasing attention for its significant clinical
efficacy in various diseases. Similarly, more and more attention has been paid in the role of …

Objective. To explore the molecular mechanism of Simiao powder in the treatment of knee
osteoarthritis. Methods. Based on oral bioavailability and drug‐likeness, the main active …