Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides

W Zhang, R Xu, J Chen, H Xiong, Y Wang… - International journal of …, 2023 - Elsevier
Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …

Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases

L Na, R Li, X Chen - Current opinion in chemical biology, 2021 - Elsevier
Sugar nucleotide-dependent glycosyltransferases (GTs) are key enzymes that catalyze the
formation of glycosidic bonds in nature. They have been increasingly applied in the …

Biotechnological advances in the synthesis of modified chondroitin towards novel biomedical applications

D Cimini, E Bedini, C Schiraldi - Biotechnology Advances, 2023 - Elsevier
Chondroitin sulfate (CS) is a well-known glycosaminoglycan present in a large variety of
animal tissues, with an outstanding structural heterogeneity mainly related to molecular …

Current state on the enzymatic synthesis of glycosaminoglycans

J Gottschalk, L Elling - Current opinion in chemical biology, 2021 - Elsevier
Glycosaminoglycans (GAGs) are linear anionic polysaccharides, and most of them show a
specific sulfation pattern. GAGs have been studied for decades, and still, new biological …

[HTML][HTML] Heterologous production of chondroitin

MR Couto, JL Rodrigues, LR Rodrigues - Biotechnology Reports, 2022 - Elsevier
Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a
popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources …

[HTML][HTML] A review of chondroitin sulfate's preparation, properties, functions, and applications

Q Shen, Y Guo, K Wang, C Zhang, Y Ma - Molecules, 2023 - mdpi.com
Chondroitin sulfate (CS) is a natural macromolecule polysaccharide that is extensively
distributed in a wide variety of organisms. CS is of great interest to researchers due to its …

[HTML][HTML] Prospects of using biocatalysis for the synthesis and modification of polymers

M Nikulin, V Švedas - Molecules, 2021 - mdpi.com
Trends in the dynamically developing application of biocatalysis for the synthesis and
modification of polymers over the past 5 years are considered, with an emphasis on the …

[HTML][HTML] Chondroitin sulfate and its derivatives: A review of microbial and other production methods

AE Awofiranye, J Hudson, AD Tithi, RJ Linhardt… - Fermentation, 2022 - mdpi.com
Chondroitin sulfate (CS) is widely used across the world as a nutraceutical and
pharmaceutical. Its high demand and potential limitations in current methods of extraction …

[HTML][HTML] Progress and challenges in the synthesis of sequence controlled polysaccharides

G Fittolani, T Tyrikos-Ergas, D Vargová… - Beilstein Journal of …, 2021 - beilstein-journals.org
The sequence, length and substitution of a polysaccharide influence its physical and
biological properties. Thus, sequence controlled polysaccharides are important targets to …

Synthesis of structurally defined chondroitin sulfate: Paving the way to the structure-activity relationship studies

Y Ji, S Zhang, M Qiao, R Jiao, J Li, P Song… - Carbohydrate …, 2020 - Elsevier
Chondroitin sulfate (CS) is one of the major and widespread glycosaminoglycans, a family of
structurally complex, linear, anionic hetero-co-polysaccharides. CS plays a vital role in …