[HTML][HTML] Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies

MA Sanchez-Garrido, M Tena-Sempere - Molecular metabolism, 2020 - Elsevier
Background Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among
reproductive age women. Although its cardinal manifestations include hyperandrogenism …

Genetic basis of polycystic ovary syndrome (PCOS): current perspectives

MJ Khan, A Ullah, S Basit - The application of clinical genetics, 2019 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is a common infertility disorder affecting a significant
proportion of the global population. It is the main cause of anovulatory infertility in women …

[HTML][HTML] Polycystic ovary syndrome: an evolutionary adaptation to lifestyle and the environment

J Parker, C O'brien, J Hawrelak, FL Gersh - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic
disorder that manifests in genetically susceptible women following a range of negative …

[HTML][HTML] The genetics of polycystic ovary syndrome: an overview of candidate gene systematic reviews and genome-wide association studies

D Hiam, A Moreno-Asso, HJ Teede, JSE Laven… - Journal of clinical …, 2019 - mdpi.com
Polycystic Ovary Syndrome (PCOS) is a complex condition with mechanisms likely to involve
the interaction between genetics and lifestyle. Familial clustering of PCOS symptoms is well …

Hyperandrogenic origins of polycystic ovary syndrome–implications for pathophysiology and therapy

DH Abbott, DA Dumesic, JE Levine - Expert review of …, 2019 - Taylor & Francis
Introduction: Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of
female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial …

[HTML][HTML] PCOS and nutritional approaches: Differences between lean and obese phenotype

L Barrea, E Frias-Toral, L Verde, F Ceriani, G Cucalón… - Metabolism Open, 2021 - Elsevier
Abstract Polycystic Ovary Syndrome (PCOS) is an endocrine/metabolic disorder with an ever-
increasing prevalence. It has various clinical characteristics; the cardinals are androgen …

Intestinal flora is a key factor in insulin resistance and contributes to the development of polycystic ovary syndrome

YL Yang, WW Zhou, S Wu, WL Tang, ZW Wang… - …, 2021 - academic.oup.com
Context The key gut microbial biomarkers for polycystic ovarian syndrome (PCOS) and how
dysbiosis causes insulin resistance and PCOS remain unclear. Objective To assess the …

[HTML][HTML] Mitochondrial dysfunction in PCOS: insights into Reproductive Organ Pathophysiology

KM Siemers, AK Klein, ML Baack - International Journal of Molecular …, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is a complex, but relatively common endocrine disorder
associated with chronic anovulation, hyperandrogenism, and micro-polycystic ovaries. In …

[HTML][HTML] Metabolomic insight into polycystic ovary syndrome—An overview

A Rajska, M Buszewska-Forajta, D Rachoń… - International journal of …, 2020 - mdpi.com
Searching for the mechanisms of the polycystic ovary syndrome (PCOS) pathophysiology
has become a crucial aspect of research performed in the last decades. However, the …

Understanding Long Covid: Nosology, social attitudes and stigma

EA Byrne - Brain, behavior, and immunity, 2022 - Elsevier
Abstract The debate around Long Covid has so far shown resistance to accept parallels
between Long Covid and a set of existing conditions which have historically been subject to …